Stefano Schiaffino - Publications

(selected, 1993-2004)

McCullagh K, Calabria E, Pallafacchina G, Ciciliot S, Serrano AL, Argentini C, Kalhovde JM, Lømo T, Schiaffino S. (2004) NFAT is a nerve activity sensor and controls activity-dependent myosin switching. Proc. Nat. Acad. Sci. USA, 101:10590-95.
Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117:399-412.
Sandri C , Di Lisi R, Picard A, Argentini C, Calabria E, Myklak K, Scartezzini P, Schiaffino S (2004) Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region. Human Genet 114:517-519.
Moreno H, Serrano A, Santalucía T , Gumà A, Cantó C, Palacín M, Schiaffino S, Zorzano A. (2003) Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle. J Biol Chem 278:40557-64.
Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G. (2003) Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. J. Mol Biol 326:137-49.
Schiaffino S, Serrano AL (2002) Calcineurin signaling and neural control of skeletal muscle fiber type and size. Trends Pharmacol Sci. 23: 569-575.
Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S. (2002) A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Nat Acad Sci USA 99:9213-18.
Serrano AL, Murgia M., Pallafacchina G, Calabria E, Coniglio P, Lømo T, Schiaffino S. (2001) Nerve activity-dependent specification of slow skeletal muscle fibers is controlled by calcineurin. Proc Nat Acad Sci USA 98:13108-13.
Murgia M, Serrano AL, Calabria E, Pallafacchina G, Lømo T, Schiaffino S. (2000) Ras is involved in nerve-activity-dependent regulation of muscle genes. Nature Cell Biol. 2:142-147.
Egeo A, Di Lisi R, Sandri C, Mazzocco M, Lapide M, Schiaffino S, Scartezzini P. (2000) Developmental expression of the SH3BGR gene mapping to the Down syndrome heart critical region. Mech Dev 90:313-316.
Weiss A, Schiaffino S, Leinwand L (1999) Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications on functional diversity. J. Mol Biol 290: 61-75.
Schiaffino S, Dallapiccola B, Di Lisi R. (1999) Molecular genetics of congenital heart disease: a problem of faulty septation. Circ Res 84:247-249.
Di Lisi R, Millino C, Calabria E, Altruda F, Schiaffino S, Ausoni S. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem 273, 25371-25380.
Gautel M, Furst D, Cocco A, Schiaffino S. (1998) Isoform transitions of the myosin-binding protein C family in developing human and mouse muscles. Lack of isoform transcomplementation in cardiac muscle. Circ Res 82: 124-129.
Schiaffino S, Salviati G (1997) Molecular diversity of myofibrillar proteins: isoforms analysis at the protein and mRNA level. Meth Cell Biol. 52: 349-369.
Schiaffino S. (1997) Protean patterns of gene expression in the heart conduction system. Circ Res 80: 749-750.
Schiaffino S, Reggiani C. (1996) Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev 76: 371-423.
Guénet JL, Simon-Chazottes D, Gravel M, K. Hastings KEM, Schiaffino S. (1995) Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7. Mamm Genome 7, 13-15
Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S. (1994) Type 2X myosin heavy chain transcripts are expressed in type 2B fibers of human skeletal muscle. Am J Physiol. 267, 1723-1728.
Bottinelli R, Betto R, Schiaffino S, Reggiani C. (1994) Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibres. J Physiol 478, 341-349.
Vitadello M, Schiaffino MV, Picard A, Scarpa M, Schiaffino S. (1994) Gene transfer in regenerating muscle. Hum Gene Ther 5, 11-18.
Ausoni S, Campione M, Picard A, Moretti P, Vitadello M, De Nardi C, Schiaffino S. (1994) Structure and regulation of the mouse cardiac troponin I gene. J Biol Chem 269, 339-346.
Schiaffino S, Reggiani C. (1994) Myosin heavy chain isoforms in mammalian skeletal muscle. J Appl Physiol 77: 493-501.
Schiaffino S, Gorza L, Ausoni S. (1993) Troponin isoform switching in the developing heart and its functional consequences. Trends Cardiovasc Med 3: 12-17.
DeNardi C, Ausoni S, Moretti P, Gorza L, Velleca M, Buckingham M, Schiaffino S. (1993) Type 2X myosin heavy chain is coded by a muscle fiber type-specific and developmentally regulated gene. J Cell Biol 123, 823-835.
Gorza L, Ausoni S, Merciai N, Hastings KEM, Schiaffino, S. (1993) Regional differences in troponin I isoform switching during rat heart development. Dev Biol 156, 253-264.
Gorza L, Schiaffino S, Volpe P. (1993) The inositol 1,4,5-triphosphate receptor in heart: evidence for its concentration in Purkinje myocytes of the conduction tissue. J Cell Biol 121, 345-353.